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Transfer of Low Dose Aspirin Into Human Milk / Palika Datta in Journal of Human Lactation, Vol. 33, n°2 (Mai 2017)
Titre : Transfer of Low Dose Aspirin Into Human Milk Type de document : texte imprimé Auteurs : Palika Datta, Auteur ; Kathleen Rewers-Felkins, Auteur ; Raja Reddy Kallem, Auteur Année de publication : 2017 Article en page(s) : pp. 296-299 Langues : Anglais (eng) Catégories : Composition du lait
Mots-clés : Aspirine Résumé : "Background:
Aspirin has antipyretic and anti-inflammatory properties and is frequently used by pregnant and lactating women. However, its transfer in human milk when administered at low dose has not been reported.
This study aimed to evaluate the transfer of acetylsalicylic acid and its metabolite, salicylic acid, into human milk following the use of low dose aspirin.
In this study, milk samples were collected at 0, 1, 2, 4, 8, 12, and 24 hours from seven breastfeeding women after a steady-state daily dose of 81 mg of aspirin. Milk levels of acetylsalicylic acid and salicylic acid were determined by liquid chromatography–tandem mass spectrometry.
Acetylsalicylic acid levels were below the limit of quantification (0.61 ng/ml) in all the milk samples, whereas salicylic acid was detected at very low concentrations. The average concentration of salicylic acid observed was 24 ng/ml and the estimated relative infant dose was 0.4%.
Acetylsalicylic acid transfer into milk is so low that it is undetectable even by highly sophisticated methodology. Salicylic acid does appear in the human milk in comparatively low amounts, which are probably subclinical in infants. Thus, the daily use of an 81-mg dose of aspirin should be considered safe during lactation." [Résumé de l'auteur]
in Journal of Human Lactation > Vol. 33, n°2 (Mai 2017) . - pp. 296-299[article]