[article]
| Titre : |
Breast Milk from Smokers Contains Less Cholesterol and Protein and Smaller Size of Apolipoprotein A-I Resulting in Lower Zebrafish Embryo Survivability |
| Titre original : |
Basic Science |
| Type de document : |
texte imprimé |
| Auteurs : |
Kim Seong-Min, Auteur ; Kim Suk-Jeong, Auteur ; Kim Jae-Ryong, Auteur |
| Année de publication : |
2017 |
| Article en page(s) : |
pp. 365-372 |
| Langues : |
Anglais (eng) |
| Catégories : |
Albumine
Anti inflammatoire
Antioxydant
Cholestérol
Composition du lait
Etude expérimentale
Fer
Protéine
Tabac
Toxique
Valeur nutritive
|
| Résumé : |
"Background: To determine the quality of breast milk (BM), we compared the functions of BM from ex-smokers and nonsmokers.
Subjects and Methods: We analyzed the contents of lipids, glucose, and protein in BM from ex-smokers (10 cigarettes/day for 13 ± 3 years) as well as infant formula.
Results: Nonsmokers' BM showed 2.4- and 1.4-fold higher cholesterol and protein contents, respectively, than BM from smokers. Infant formula contained almost no cholesterol, but did show remarkably higher glucose and triglyceride levels than BM. Microinjection of BM (50 nL) from nonsmokers and smokers into zebrafish embryos resulted in 59% and 44% survival, respectively, whereas formula injection resulted in 31% survival. The higher cholesterol and protein contents of BM were directly correlated with higher embryo survivability, suggesting that cholesterol content is directly and critically associated with growth of neonate infants. Smokers' BM contained smaller-sized apolipoproteinA-I (apoA-I) (24.4 ± 0.2 kDa) than BM from nonsmokers (26.7 ± 0.4 kDa), suggesting that putative modification and cleavage occurred in apoA-I. BM containing higher molecular weight apoA-I resulted in higher embryo survivability.
Conclusions: Smoking before pregnancy can affect the composition and quality of BM, resulting in almost complete loss of cholesterol and protein, especially lactoferrin, lactalbumin, and apoA-I, accompanied by proteolytic degradation. These impairment effects of BM are associated with elevation of oxidative stress and lower embryo survivability." [Résumé de l'auteur] |
| Permalink : |
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in Breastfeeding Medicine > Vol. 12, n°6 (Juillet - Août 2017) . - pp. 365-372
[article]
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Accueil
Ajouter le résultat dans votre panier Faire une suggestion Affiner la recherche Interroger des sources externesAbstracts from The Academy of Breastfeeding Medicine 22nd Annual International Meeting Atlanta, Georgia November 9–12, 2017 in Breastfeeding Medicine, Vol. 12, S1 (Octobre 2017)
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