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Breast Milk from Smokers Contains Less Cholesterol and Protein and Smaller Size of Apolipoprotein A-I Resulting in Lower Zebrafish Embryo Survivability / Kim Seong-Min in Breastfeeding Medicine, Vol. 12, n°6 (Juillet - Août 2017)
Titre : Breast Milk from Smokers Contains Less Cholesterol and Protein and Smaller Size of Apolipoprotein A-I Resulting in Lower Zebrafish Embryo Survivability Titre original : Basic Science Type de document : texte imprimé Auteurs : Kim Seong-Min, Auteur ; Kim Suk-Jeong, Auteur ; Kim Jae-Ryong, Auteur Année de publication : 2017 Article en page(s) : pp. 365-372 Langues : Anglais (eng) Catégories : Albumine
Composition du lait
Résumé : "Background: To determine the quality of breast milk (BM), we compared the functions of BM from ex-smokers and nonsmokers.
Subjects and Methods: We analyzed the contents of lipids, glucose, and protein in BM from ex-smokers (10 cigarettes/day for 13 ± 3 years) as well as infant formula.
Results: Nonsmokers' BM showed 2.4- and 1.4-fold higher cholesterol and protein contents, respectively, than BM from smokers. Infant formula contained almost no cholesterol, but did show remarkably higher glucose and triglyceride levels than BM. Microinjection of BM (50 nL) from nonsmokers and smokers into zebrafish embryos resulted in 59% and 44% survival, respectively, whereas formula injection resulted in 31% survival. The higher cholesterol and protein contents of BM were directly correlated with higher embryo survivability, suggesting that cholesterol content is directly and critically associated with growth of neonate infants. Smokers' BM contained smaller-sized apolipoproteinA-I (apoA-I) (24.4 ± 0.2 kDa) than BM from nonsmokers (26.7 ± 0.4 kDa), suggesting that putative modification and cleavage occurred in apoA-I. BM containing higher molecular weight apoA-I resulted in higher embryo survivability.
Conclusions: Smoking before pregnancy can affect the composition and quality of BM, resulting in almost complete loss of cholesterol and protein, especially lactoferrin, lactalbumin, and apoA-I, accompanied by proteolytic degradation. These impairment effects of BM are associated with elevation of oxidative stress and lower embryo survivability." [Résumé de l'auteur]
in Breastfeeding Medicine > Vol. 12, n°6 (Juillet - Août 2017) . - pp. 365-372[article]Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk Fortifier / Amanjot Sandhu in Breastfeeding Medicine, Vol 12, n°9 (Novembre 2017)
Titre : Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk Fortifier Type de document : texte imprimé Auteurs : Amanjot Sandhu, Auteur ; Sharla Fast, Auteur ; Kari Bonnar, Auteur ; Ronald John Baier, Auteur ; Michael Narvey, Auteur Année de publication : 2017 Article en page(s) : pp. 570-573 Langues : Anglais (eng) Catégories : Canada
Etude de cas ou de cohorte
Grand prématuré (avant 34 semaines)
Nourrisson très faible poids à la naissance
Mots-clés : Fortifiant à base de protéines bovines, fortifiant à base de lait maternel, intolérance Résumé : "Objective: To describe the results of utilizing a human milk-based human milk fortifier (HMHMF) as rescue therapy to meet nutritional requirements in very low birth weight and preterm infants demonstrating feeding intolerance to bovine-based human milk fortifier (BHMF) in the Canadian Neonatal Intensive Care Unit (NICU) setting.
Materials and Methods: At two Level III NICUs in Winnipeg, MB, Canada, a rescue protocol was implemented to provide HMHMF for infants demonstrating intolerance to BHMF. To qualify for rescue, infants were required to experience two episodes of significant gastrointestinal (GI) symptoms associated with fortification with BHMF. A case series report was conducted retrospectively examining the success of rescue therapy, growth rates, protein, and calorie intakes before and after initiation of HMHMF in seven infants.
Results: Seven infants (birth weight 723 ± 247 g, gestation 25.3 ± 3.4 weeks) were treated with rescue fortification with HMHMF. All infants were transitioned off parenteral nutrition (PN) without relapse of GI symptoms. Growth rate, protein, and calorie intakes improved with the use of HMHMF.
Conclusions: Very low birth weight and preterm infants with GI intolerance to BHMF were successfully rescued with use of HMHMF. Improvements in growth were achieved without need for supplementation with PN through achievement of sufficient enteral calorie and protein intakes."[résumé de l'auteur]
in Breastfeeding Medicine > Vol 12, n°9 (Novembre 2017) . - pp. 570-573[article]The Use of Theory in Qualitative Research / Dawn Leeming in Journal of Human Lactation, Vol. 34, n°4 (Novembre 2018)
Titre : The Use of Theory in Qualitative Research Type de document : texte imprimé Auteurs : Dawn Leeming, Auteur Année de publication : 2018 Article en page(s) : pp. 668-673 Langues : Anglais (eng) Catégories : Etude et article scientifique
Note de contenu : "Compared with quantitative research, qualitative research has a varying and even troubled relationship with theory (Bendassolli, 2014). Quantitative methods were developed as a means of testing theoretically derived hypotheses, for example, when x happens, y will occur. Although there are some atheoretical quantitative studies—for example, investigating the outcome of an intervention—often the theory being tested in a quantitative study is explained when the hypotheses are introduced. However, the position of theory is not always so predictable, or even visible, in qualitative research. Sometimes the aim of qualitative research is to build a novel theory, ensuring that it is developed from the data rather than from ideas that the researcher has brought to the research. At other times, prior theory or broader theoretical frameworks play a significant role in framing a qualitative study, guiding data collection and/or analysis. Alternatively, several theoretical concepts might be used selectively to make sense of findings rather than using the findings to test the theory, as in quantitative research." [Extrait de l'article] Permalink :
in Journal of Human Lactation > Vol. 34, n°4 (Novembre 2018) . - pp. 668-673[article]