| Titre : | Evaluating the Effect of a 14-Day Course of Domperidone on Breast Milk Production: A Per-Protocol Analysis from the EMPOWER Trial (2019) |
| Auteurs : | Elizabeth V. Asztalos, Auteur ; Alex Kiss, Auteur ; Orlando P. daSilva, Auteur |
| Type de document : | Article : texte imprimé |
| Dans : | Breastfeeding Medicine (Vol 14, n°2, Mars 2019) |
| Article en page(s) : | pp. 102-107 |
| Langues: | Anglais |
| Catégories : | Dompéridone ; Ejection lait ; Galactogogue ; Lactation ; Prématurité (avant 37 semaines) ; Volume de lait |
| Résumé : |
Background
Galactogogues are often considered when mothers of very preterm infants experience challenges in producing adequate amounts of breast milk. We conducted a per-protocol analysis of those mothers who completed a 14-day course of domperidone during the EMPOWER trial. Our primary aim was to evaluate the response to a completed course of domperidone and whether the response was affected by the timing of the initiation of intervention. Methods For this analysis, 83 mothers of infants ≤29 weeks gestation were included: 45 mothers who received domperidone from days 1 to 14 of the trial study treatment period and 38 mothers who received domperidone from days 15 to 28. Domperidone was given at a dose of 10 mg thrice daily for 14 days. The primary outcome was the proportion of mothers who achieved a modest 50% increase in breast milk volume from the volume at the end of the 2-week period of treatment of domperidone. Results When adjusted for the initiation of domperidone treatment, the proportion of mothers in the days 1–14 group (77.8%) was similar compared to those in the days 15–28 group (65.8%), OR 1.96 (95% CI 0.72–5.32; p = 0.19). Conclusion Taking into consideration potential limitations in power, this secondary analysis was able to show that the mothers in the EMPOWER study who were identified as actually completing a 14-day treatment course responded irrespective of the timing of their initiation of domperidone and demonstrated a modest increase in breast milk volume. |
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